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Vascular response to infusions of a non-extravasating hemoglobin polymer,
Barbara Matheson, Herman E. Kwansa, Enrico Bucci, Annette Rebel, and Raymond C. Koehler , J Appl Physiol 93: 1479-1486, 2002; doi:10.1152/japplphysiol.00191.2002
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Cerebral blood flow during hypoxic hypoxia with plasma-based hemoglobin at reduced hematocrit , John A. Ulatowski, Enrico Bucci, Anna Razynska, Richard J. Traystman, and Raymond C. Koehler, Am J Physiol Heart Circ Physiol 274: H1933-H1942, 1998; Vol. 274, Issue 6
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Cerebrovascular response to decreased hematocrit: effect of cell-free hemoglobin, plasma viscosity, and CO2 , Annette Rebel, John A. Ulatowski, Herman Kwansa, Enrico Bucci,
and Raymond C. Koehler, Am J Physiol Heart Circ Physiol 285: H1600-H1608, 2003; doi:10.1152/ajpheart.00077.2003
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Role of nitric oxide scavenging in vascular response to cell-free hemoglobin transfusion, Kenji Sampei, John A. Ulatowski, Yoshio Asano, Herman Kwansa, Enrico Bucci, and Raymond C. Koehler, Am J Physiol Heart Circ Physiol. 2005 Sep; 289(3): H1191–H1201. Published online 2005 May 13. doi: 10.1152/ajpheart.00251.2005
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Effect of cross-linked hemoglobin transfusion on endothelial-dependent dilation in cat pial arterioles , Yoshio Asano, Raymond C. Koehler, John A. Ulatowski, Richard J. Traystman, and Enrico Bucci , Am J Physiol Heart Circ Physiol 275: H1313-H1321, 1998; Vol. 275, Issue 4, H1313-H1321
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Base-line O2 extraction influences cerebral blood flow response to hematocrit,
M. L. Hudak, Y. L. Tang, J. Massik, R. C. Koehler, R. J. Traystman and M. D. Jones Jr, Am J Physiol Heart Circ Physiol 254: H156-H162, 1988;
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Entropy-Driven Intermediate Steps of Oxygenation May Regulate the Allosteric Behavior of Hemoglobin, Enrico Bucci, Zygmunt Gryczynski, Anna Razynska, and Herman Kwansa, Biophys J, May 1998, p. 2638-2648, Vol. 74, No. 5
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Positive and negative Cooperativities at Subsequent Steps of Oxygenation Regulate the Allostetic Behavior of Multistate Sebacylhemoglobin, E.Bucci, A.Razynska, H.Kwansa, K.Gryczynski. Biochemistry, 1996, 35 (11), pp 3418–3425 DOI: 10.1021/bi952446b
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Regional cerebral blood flow in cats with cross-linked hemoglobin transfusion during focal cerebral ischemia, Rebel, Ulatowski, Joung, Bucci, Traystman, Koehler, Am.J.Physiol Heart Circ Physiol 282:832-841, 2002
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Zero-link Polymerization: a new Class of Polymeric Hemoglobins, A. Razynska, E. Bucci, Chapter 21 Blood Substitutes – Present and Future Perspectives, E.Tsuchida (Editor), 1998
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Production and characteristics of an infusible oxygen-carrying fluid based on hemoglobin intramoleculary cross-linked with sebacic acid, E. Bucci, A. Razynska, H. Kwansa, B. Mathenson-Urbaitis, M. O’Hearne, J.A. Ulatowski, R. C. Koehler, The Journal of Laboratory and Clinical Medicine Volume 128, p-146-153, Published Aug-1996.
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Adipyl Crosslinked Bovine Hemoglobins as New Models of Allosteric Systems, H. Kwansa, A. DeYoung, D. Arosio, A. Razynska, E. Bucci, Proteins: Structure, Functions, and Genetics 39:166-169 (2000)
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Vascular Response to Infusions of a Non Extravasating Hemoglobin Polymer, B. Mathenson, H. E. Kwansa, E. Bucci, A. Rebel, R. C. Koehler, J.Apply Physiol 93: 1479-1486, 2002.
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Dependence of Acetylcholine and ADP dilation of pial arterioles on heme oxygenase after transfusion of cell-free polymeric hemoglobin, A.Rebel, Suyi Cao, H. Kwansa, S.Dore, Enrico Bucci and Raymond C. Koehler, Am J. Physiol Heart Circ Physiol (Oct. 7, 2005)
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Role of 20-HETE in the pial arteriolar constrictor response to decreased hematocrit after exchange transfusion of cell-free polymeric hemoglobin, X.Quin, H.Kwansa, E. Bucci, R. J. Roman, R. C. Koechler, J. Appl. Physiol (September 15, 2005)
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Decreased damage from transient focal cerebral ischemia by transfusion of zero-link hemoglobin polymers in mouse, T. Mito, M Nemoto, H. Kwansa, K. Sampei, M. Habeeb, S. J. Murphy, E. Bucci, R. C. Koehler, Stroke. 2009 Jan;40(1):278-84. doi: 10.1161/STROKEAHA.108.526731. Epub 2008 Nov 6.
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Does OxyVita, a New-Generation Hemoglobin-Based Oxygen Carrier, or Oxyglobin Acutely Interfere With Coagulation Compared With Normal Saline or 6% Hetastarch? An Ex Vivo Thromboelastography Study, J. Jahr, Journal of Cardiothoracic and Vascular Anesthesia, Volume 22, Issue 1, Pages 34-39
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Basic science focus on blood substitutes: a summary of the NHLBI Division of Blood Diseases and Resources Working Group Workshop, March 1, 2006, Timothy Estep, Enrico Bucci, Martha Farmer, Gerson Greenburg, John Harrington, Hae Won Kim, Harvey Klein, Phyllis Mitchell, George Nemo, Klen Plsen, Andre Palmer, C. Robert Valeri, and Robert Winslow. Review - TRANSFUSION, Volume 48, April 2008
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Effects of cross-linking and zero-link polymerization on oxygen transport and redox chemistry of bovine hemoglobin, Yiping Jia, Abdu I. Alayash, BBA – Proteins and Proteomics (2009), doi: 10.1016/j.bbapap.2009.04.008
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Thermodynamic approach to oxygen delivery in vivo by natural and artificial oxygen carriers, Enrico Bucci, Biophysical Chemistry 142 (2009) 1-6
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Structural and Redox Behavior of OxyVita™ - a Zero-Linked Polymeric Hemoglobin: Comparison with Natural Acellular Polymeric Hemoglobins, John P. Harrington, Jacek Wollocko and Hanna Wollocko, Artif Cells Blood Substit Immobil Biotechnol. 2010 Apr;38(2):64-8. doi: 10.3109/10731191003634562.
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Development of Zero-Link Polymers of Hemoglobin, Which do not Extravasate and do not Induce Pressure Increases upon Infusion, Enrico Bucci and Herman Kwansa, Raymond C. Koehler, Barbara Mathenson, Artif Cells Blood Substit Immobil Biotechnol. 2007; 35(1): 11–18. doi: 10.1080/10731190600974277
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Basic science offers a challenge for developing hemoglobin based oxygen carriers into therapeutic agents, Enrico Bucci, Artificial Cells, Blood Substitutes, and Biotechnology
Volume 39, 2011 - Issue 4
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Ligand Exchange (CO→O2): Increased Structural and Redox Stability for Zero-Linked Polymeric OxyVita® Hemoglobin, a Hemoglobin-Based-Oxygen-Carrier, Jacek Wollocko, Joseph Branco and John P. Harrington, Biophysical Journal, 100(3) Suppl.1, 2011
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Physicochemical Characteristics of OxyVita Hemoglobin, a Zero-Linked Polymer: Liquid and Powder Preparations, John P Harrington, Jacek Wollocko, Edyta Kostecki, Hanna Wollocko,
Artificial cells, blood substitutes, and immobilization biotechnology 1532-4184 , 2010 Jul
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Hierarchical Structures of Natural Acellular Polymeric Hemoglobins: Model for Design of a Therapeutic Hemoglobin-Based-Oxygen-Carrier (HBOC), John P. Harrington, Kseniya Orlik, Hanna Wollocko, Jacek Wollocko, Biophysical Journal, Vol 96 issue3 - 2255-POS BOARD#B225
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Pre-clinical studies using OxyVita hemoglobin, a zero-linked polymeric hemoglobin: a review, John P. Harrington and Hanna Wollocko, J Artif Organs 13:183 (2010) PMID 21127928
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Molecular Design Properties of OxyVita Hemoglobin, a New Generation Therapeutic Oxygen Carrier: A Review, John P. Harrington and Hanna Wollocko. J. Funct. Biomaterial. 2011, 2, 414-424; doi:10.3390/jfb2040414
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Effects of Top-loading a Zero-link Bovine Hemoglobin (ZL-HbBv), OxyVitaTM, on Systemic and Microcirculatory Variables, Bjorn Kyungsuck Song, PhD, William H. Nugent,PhD, Paula F. Moon-Massat, DVM, Charles R. Auker,MD, PhD, Richard McCarron,PhD, and Roland N Pittman,PhD, Military Medicine 178(5):570-577.
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Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics, John P. Harrington and Hanna Wollocko, Book Chapter, Textbook: Hemoglobin Based Oxygen Carriers and Red Cell Substitutes and Oxygen Therapeutics, 2013, Springer, Chapter 15, Pages 283-297.
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Low-volume resuscitation cocktail extends survival after severe hemorrhagic shock, Reynolds PS, Barbee RW, Skaflen MD, Ward KR, Shock. 2007 Jul;28(1):45-52.
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Effects of the Oxygen-Carrying Solution OxyVita C on the Cerebral Microcirculation and Systemic Blood Pressures in Healthy Rats, Rania Abutarboush, Chioma Aligbe, Georgina Pappas, Biswajit Saha, Francoise Arnaud, Ashraful Haque, Charles Auker, Richard McCarron, Anke Scultetus and Paula Moon-Massat, J. Funct. Biomater. 2014, 5, 246-258; doi:10.3390/jfb5040246
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OxyVita®C, a Next-generation Haemoglobin-based Oxygen Carrier, with Coagulation Capacity (OVCCC). Modified Lyophilization/Spray-drying Process: Proteins Protection, Wollocko H, Wollocko BM, Wollocko J, Grzegorzewski W, Smyk L, Artificial Cells, Nanomedicine, and Biotechnology, 2017; vol.45, no.7.,
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Zero-link Polymerized Hemoglobin (OxyVita®Hb) Stabilizes the Heme Environment: Potential for Lowering Vascular Oxidative Stress, Wollocko H, Anvery S, Wollocko J, Harrington JM, Harrington JP, Artificial Cells, Nanomedicine, and Biotechnology, 2017; vol.45, no. 4.,
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An Overview of Therapy Guidelines for Cardiac Arrest and the Potential Benefits of Hemoglobin-Based Oxygen Carriers, Wollocko BM, Papian-Gorji B, Yen W, Zahid U, Shah N, Steier K, Wollocko H. MDPI Cardiogenetics 2022, 12, 37-48, Published Jan 20, 2022.
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OxyVita Hb: A Step Forward in Delivering Oxygen Carrying Capacity for Therapeutic Applications, Wollocko H, Harrington JP, Jahr J, Steier K, Wollocko J. Hardcover & ebook: Nanobiotherapeutic Based Blood Substitutes, Chapter 7.2, Pages 903-934; World Scientific Publishing Co. Pte. Ltd, 2022.
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OxyVita: History, Studies, and Future, Wollocko, H., Wollocko, J., Jahr, J., & Steier, K. (2022). In: Book - Blood Substitutes and Oxygen Biotherapeutics, Chapter 25, Springer, Cham. doi:10.1007/978-3-030-95975-3_25
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